Felix Dubois enrolled in the nursing program at General Hospital and befriended fellow nursing student Sabrina Santiago. During this time, Sabrina and Felix became best friends and Felix encouraged Sabrina to make a move on her crush, Dr. Patrick Drake. Another doctor, Britt Westbourne, was also interested in Patrick and often manipulated Patrick and Sabrina in order to keep them apart. Felix helped Sabrina deal with Britt's scheming and helped Sabrina put together the 2013 Nurses Ball. Sabrina and Felix graduated with their nursing degrees and were both hired at the hospital.

Eventually Sabrina and Patrick began to date while Britt announced that she was pregnant with Patrick's child. Felix and Sabrina believed that Britt was using the pregnancy to win Patrick and Felix vowed to help Sabrina bring Britt down. Felix also offered relationship advice to several other Port Charles residents although he remained single.